Hydrodynamic behaviour of anti-reflux needle-free connectors during microinfusion with syringe pump: A bench-top study

Neutral displacement NFCs equipped with anti-reflux valves did not show evidence of altered infusion regularity under the experimental conditions tested. The results of this study suggest that using anti-reflux NFCs for the continuous delivery of drugs with a narrow therapeutic range may be considered compatible with low-flow infusion under controlled experimental conditions. This study represents a preliminary step toward further investigations on anti-reflux NFCs during syringe pump infusion and changeover.