Comparison of the Effect of Functionalised Nanotubes/Nano-reservoirs as Drug Delivery Systems in Periodontal Regeneration – A Systematic Review

Abstract Introduction: Functionalised carbon nanotubes (CNTs) are explored for their ability to enhance scaffold properties without compromising biocompatibility. This systematic review assesses studies on functionalised CNTs in periodontal tissue regeneration, synthesising evidence on their effectiveness in managing periodontitis and periimplantitis. Materials and Methods: Between March 2014 and April 2024, a comprehensive mixedmatch search was carried out using PubMed, PubMed Advanced, Scopus, The Cochrane Library (CDSR, CENTRAL and DARE) and Thomson Reuters Web of Science. The selected eight studies were assessed for quality using the risk of bias 2 (ROB2) tool. Results: From the 8 included studies, data regarding the subsequent parameters was taken out. Data extraction of included studieds was done along with risk of bias assessment. Conclusion: This study presents an overview of the use of functionalised and nonfunctionalised nanotubes as delivery routes for bioactive compounds and medications, as well as the functionalisation of these nanotubes to support periodontal regeneration.