PTTG3P-miR-142-5p-IGF2BP3 axis governs ferroptosis in hepatocellular carcinoma

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Authors

Wenjuan Zhang · Chengde Medical University

Hao Qiang Liu · Chengde Medical University

Shuhan Zhang · Air Force General Hospital PLA

Zhiyan Li · Chengde Medical University

Shifan Shi · Chengde Medical University

Jiahui Lu · Chengde Medical University

Yingmei Gao ·

Abstract

The PTTG3P/miR-142-5p/IGF2BP3 axis is a master regulator of ferroptosis in HCC. PTTG3P is a competing endogenous RNA (ceRNA) which sustains IGF2BP3-mediated ferroptosis resistance. Targeting the axis sensitizes HCC to ferroptosis and is potentially a novel therapeutic target to combat treatment resistance.

Topics & Keywords

Ferroptosis and cancer prognosis Clusterin in disease pathology Cholangiocarcinoma and Gallbladder Cancer Studies

Publication Details

Published in: Discover Oncology

DOI: 10.1007/s12672-026-04902-8

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PTTG3P-miR-142-5p-IGF2BP3 axis governs ferroptosis in hepatocellular carcinoma

Authors

Abstract

Topics & Keywords

Publication Details