Ferroptosis inhibition and mitochondrial rescue: a novel mechanism of emodin in rheumatoid arthritis

20260 citationsJournal Articlegold Open Access

Authors

L B Zhou · The Affiliated Yongchuan Hospital of Chongqing Medical University

Jing Ren · Chongqing Medical and Pharmaceutical College

Dehao Du · The Affiliated Yongchuan Hospital of Chongqing Medical University

Xiaofeng Rong · The Affiliated Yongchuan Hospital of Chongqing Medical University

Abstract

EMO ameliorates experimental arthritis mainly by suppressing ferroptosis via the GPX4/ACSL4 axis, highlighting ferroptosis as a previously underappreciated therapeutic target in RA and supporting EMO as a potential adjunctive treatment for RA.

Topics & Keywords

Ferroptosis and cancer prognosis Immune cells in cancer Cancer-related molecular mechanisms research

Publication Details

Published in: Redox Report

Volume 31, Issue 1, pp. 2646383-2646383

DOI: 10.1080/13510002.2026.2646383

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Ferroptosis inhibition and mitochondrial rescue: a novel mechanism of emodin in rheumatoid arthritis

Authors

Abstract

Topics & Keywords

Publication Details