Complete NUB1 depletion in ER-negative breast cancer progression in paired primary–metastatic cases: a case series

Loss of NEDD8 ultimate buster 1 in metastases may signal a transition from hypoxia-driven nuclear localization to unchecked metastatic progression. These findings highlight NEDD8 ultimate buster 1 as a potential prognostic marker and therapeutic stratifier, warranting larger studies to confirm its mechanistic and clinical relevance.