Clinical High-Risk for Psychosis in Adolescents: Updated Meta-Analysis on Transition Rates and Antipsychotic Prognostic Value

CHR-P criteria demonstrate prognostic validity in developmental populations, with transition rates in adolescents comparable to young adult cohorts and significantly higher than in CHR-P negative adolescents. In line with previous research in adult CHR-P, the need of AP at baseline is substantially associated with an increased risk for transition. Future research should broaden prognostic focus beyond transition alone to capture remission, persistence, and functional outcomes in this vulnerable group.