Adipose-driven complement-lipid reprogramming controls nociceptive vulnerability in obesity-associated osteoarthritis

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Authors

Hope D. Welhaven · University of California, San Francisco

Joseph B Lesnak · The University of Texas at Dallas

Kristin L. Lenz · Washington University in St. Louis

Bethany A. Andoko · University of California, San Francisco

Arin K. Oestreich · Washington University in St. Louis

Ashley N. Plumb · The University of Texas at Dallas

Katelyn E. Sadler

Abstract

We identify an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, providing a mechanistic basis for pain-structure discordance in obesity-associated osteoarthritis.

Topics & Keywords

Pain Mechanisms and Treatments Osteoarthritis Treatment and Mechanisms Neuropeptides and Animal Physiology

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.03.19.712962

Field-Weighted Citation Impact: 0.00

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Adipose-driven complement-lipid reprogramming controls nociceptive vulnerability in obesity-associated osteoarthritis

Authors

Abstract

Topics & Keywords

Publication Details