Risk of CNS relapse following pathological complete response to neoadjuvant chemotherapy in early breast cancer

20260 citationsJournal Articlehybrid Open Access

Authors

Luciana de Moura Leite · AC Camargo Hospital

Guilherme Rossato de Almeida · AC Camargo Hospital

Monique Celeste Tavares · AC Camargo Hospital

Marcelle Goldner Cesca · AC Camargo Hospital

Fernando Augusto Batista Campos · AC Camargo Hospital

Fernanda Alves de Oliveira · AC Camargo Hospital

Débora Maciel Santana Dornellas

Abstract

Although pCR was not associated with a lower overall risk of CNS recurrence, it predicted a reduced risk in HER2-positive disease. Isolated CNS relapse predominated, suggesting a sanctuary effect.

Topics & Keywords

Brain Metastases and Treatment Breast Cancer Treatment Studies Cancer-related cognitive impairment studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Breast Cancer Research and Treatment

Volume 216, Issue 3

DOI: 10.1007/s10549-026-07915-7

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