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Vulvar cancer is a rare pathology that most often affects women in their 3rd decade of life, with co-morbidities. The first-line treatment for vulvar cancer is surgery, which is associated with high morbidity rates. Preventing or minimizing surgery is an important objective, as it impacts on patients' quality of life, and is highly deleterious in elderly patients, the majority of whom are affected by this pathology. Objectives: The aim of this study was to carry out 2 retrospective multicentre observational studies to evaluate tumour size and the achievement of healthy excision margins as a function of patient age. A literature review and meta-analysis of post-operative complications of surgical management of vulvar cancer will be performed to assess the impact of frailty factors. Materials and method: We conducted 2 observational, retrospective, cohort-type studies, enabling a uni- and multivariate analysis of a population of patients presenting with vulvar cancer, as well as survival curves as a function of age (<65 years and ≥ 65 years and in extreme ages ≥80 years). We then carried out an exhaustive bibliographic search for studies relevant to the question posed and performed a qualitative study of these. Statistical analysis of the studies required the use of a random effect, and the Mantel-Haenszel method was chosen to combine the results of the studies. Result: Our retrospective studies showed that patients aged ≥ 65 years had larger vulvar cancers than patients < 65 years. This hypothesis was confirmed in extreme ages (≥ 80 years). Multivariate analysis revealed that age alone was a risk factor for larger vulvar cancers. Despite the larger tumour size, there was no significant difference in obtaining healthy surgical excision margins according to patient age. Our literature review and meta-analysis did not allow us to draw any significant conclusions regarding the impact of frailty, particularly age-related frailty, on the occurrence of postoperative complications, due to the absence of age groups or frailty scores in these retrospective studies, the different definitions of complications, the lack of precision in the data provided, and the variety of surgeries performed. Despite the lack of conclusions in this study, it seems that the complications of vulvar cancer surgery depend closely in each case on the patient's fragility linked to her age and general condition (comorbidities), associated with the size, location and stage of the tumour, as well as the condition of the surrounding tissues. Discussion: Screening for pre-cancerous lesions and early diagnosis of vulvar cancer is crucial to avoid surgery, particularly inguino-femoral lymphadenectomy, which appears to be one of the most important factors in minimizing short- and long-term complications.