Dapagliflozin and Crocin Ameliorate DOX-Induced Cardiotoxicity in Rats via Activating the Nrf-2/HO-1/NQO1 Pathway: A Comparative Study

20260 citationsJournal Article

Authors

Anwaar M. Shaban · Menoufia University

Eman Ali · Universitas 17 Agustus 1945 Semarang

Mohd Khalil · Menoufia University

Marwa Omar · Department of Embryology

Yousra Ali Rohem Al-Ghalban · Menoufia University

Eman I. El-Gizawy · Menoufia University

Abstract

DAPA is a promising new cardioprotective medication against DOX-related cardiotoxicity. Cardiotoxicity is better controlled with DAPA than Cr by suppressing oxidative stress, apoptosis, and upregulation of the antioxidant Nrf-2/HO-1/NQO1 genes.

Topics & Keywords

Saffron Plant Research Studies Flavonoids in Medical Research Phytochemicals and Antioxidant Activities

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Immunopharmacology and Immunotoxicology

DOI: 10.1080/08923973.2026.2648210

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