The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles

The rise of antimicrobial resistance (AMR) is one of the greatest health threats facing the world today. Supramolecular self-associating amphiphiles (SSAs) have shown potential for development as novel antimicrobial agents. We now move to explore the systematic use of nonclassical bioisosteres within these systems for the first time, reporting enhanced antimicrobial efficacy against a variety of clinically relevent bacteria as a result.