Administration of melatonin in small intestine damage induced by flattening filter and flattening filter free radiotherapy in rat: a histopathological and biochemical study

Melatonin significantly reduced radiotherapy-induced oxidative stress and apoptosis in healthy small intestinal tissue histopathologically and biochemically. These findings suggest that melatonin may act as an effective radioprotective agent by preserving small intestinal integrity during abdominopelvic radiotherapy.