Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

The study highlighted two distinct protective effects of nintedanib on lung fibrosis. One well-known on mesenchymal cells and matrix-related components. Plus, one related to the involvement of the pneumocyte-macrophage paracrine lipid axis, where oxidized lipids alter macrophage activities, leading to the formation of lipid-filled macrophages. This may open new research directions.