Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours

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Authors

Héléne T. Cronjé

Sile Hu

Rachel Gurrell · Aptevo Therapeutics (United Kingdom)

M. Vujkovic · Translational Therapeutics (United States)

Susanna C. Larsson · Uppsala University

Richard Mason · University of Cambridge

R. Butt · Aptevo Therapeutics (United Kingdom)

Dipender Gill

Abstract

This study identifies a genetic instrument for FGF21 effects to provide causal human evidence supporting favourable effects of FGF21 analogues for the treatment of AUD and related traits, as well as on metabolic outcomes more broadly. Further clinical study is duly warranted.

Topics & Keywords

Fibroblast Growth Factor Research Genetic Associations and Epidemiology Regulation of Appetite and Obesity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Medicine

DOI: 10.1186/s12916-026-04807-x

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