Synthesis and Properties of 1,3-Disubstituted Ureas Based on a Naphthyl Propionic Acid Derivative Naproxen

A series of 1,3-disubstituted ureas was synthesized in 85–93% yield by the reaction of 2-(1-isocyanatoethyl)-6-methoxynaphthalene with adamantyl-containing, cyclic, and aromatic amines. The synthesized ureas are promising inhibitors of human soluble epoxide hydrolase (sEH) and potential inhibitors of cyclooxygenase (COX-2).