Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model

20260 citationsJournal Articlehybrid Open Access

Authors

Muyiwa Awoniyi · University of North Carolina at Chapel Hill

Mohamed El Hag · Cleveland Clinic

Josue Hernandez · Cleveland Clinic Lerner College of Medicine

Qijun Yang · Cleveland Clinic

Nicholas Evans · Cleveland Clinic Lerner College of Medicine

Ina Nemet · Cleveland Clinic Lerner College of Medicine

Billy Ngo

Abstract

PSC-UC neoplasia associates with transmissible microbiota-dependent inflammation and secondary BA deficiency. Controlled restoration of BA-transforming microbial functions, rather than indiscriminate secondary BA replacement, is a rational translational direction.

Topics & Keywords

Liver Diseases and Immunity Gut microbiota and health Inflammatory Bowel Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

DOI: 10.1136/gutjnl-2025-336675

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