Temporal association between NRF2/HO-1 activation, endogenous BDNF up-regulation, and motor recovery in a male mouse MCAO model

20260 citationsJournal Articlegold Open Access

Authors

Junghee Park · Chosun University

Hyoin Jeon Heera Yang Dongwook Seo Kyu Lim Wonmin Hwang · Chosun University

HYEKYOUNG SHIN · Chosun University

YOONYOUNG CHUNG · Chosun University

D. Kim · Chosun University Hospital

Yonghyun Jun · Chosun University

Abstract

These findings indicate that activation of the NRF2/HO-1 pathway is temporally associated with increased expression of endogenous BDNF and recovery of motor function following ischemic injury in male mice.

Topics & Keywords

Genomics, phytochemicals, and oxidative stress Nerve injury and regeneration Spinal Cord Injury Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Stroke and Cerebrovascular Diseases

Volume 35, Issue 5, pp. 108616-108616

DOI: 10.1016/j.jstrokecerebrovasdis.2026.108616

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