A Mitochondrial Plasma Proteomic Signature Identifies Metastatic Chromophobe Renal Cell Carcinoma

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Authors

Clara Steiner · Dana-Farber Cancer Institute

Tiegang Han · Brigham and Women's Hospital

Steven Safi · Brigham and Women's Hospital

Wafaa Bzeih · Brigham and Women's Hospital

Hadi Mansour · Brigham and Women's Hospital

Eddy Saad · Beth Israel Deaconess Medical Center

Jessica F. Williams

Abstract

Compared to ccRCC, the plasma proteome of metastatic ChRCC is dominated by mitochondrial metabolic enzymes, revealing a systemic metabolic phenotype strikingly aligned with the known histologic accumulation of abnormal mitochondria in ChRCC cells.

Topics & Keywords

Renal cell carcinoma treatment Cancer, Hypoxia, and Metabolism Clusterin in disease pathology

Publication Details

Published in: Cancers

Volume 18, Issue 6, pp. 1032-1032

DOI: 10.3390/cancers18061032

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A Mitochondrial Plasma Proteomic Signature Identifies Metastatic Chromophobe Renal Cell Carcinoma

Authors

Abstract

Topics & Keywords

Publication Details