Investigation of Walking Ability in 161 Patients With Duchenne Muscular Dystrophy

We aimed to identify modifiable risk factors affecting ambulation in Chinese children with Duchenne muscular dystrophy (DMD) by analyzing follow-up data from 161 patients with DMD. Continuous variables were compared using <i>t</i>-test or the Wilcoxon rank-sum test (for non-normally distributed variables). Cox regression determined factors influencing walking ability, and the log-rank test compared retention of walking ability between school-going and non-school-going patients. Hormone therapy (HR 3.72; <i>P</i> = .033), school attendance (HR 5.20; <i>P</i> = .010), and Disability and Social Support Rating Scale scores (HR 1.16; <i>P</i> = .021) significantly predicted loss of ambulation. Vitamin D levels were lower in ambulatory children with DMD who lost the ability to walk (F = 26.246, <i>P</i> = .000). Hormone therapy improved the 10-m walking time, while rehabilitation influenced the decumbent position and walking times. Early hormone therapy combined with consistent rehabilitation and school engagement is recommended for preserving ambulation.