From sedation to stimulation: anecdotal case reports of enhanced sexual arousal in men and women taking diphenhydramine hydrochloride

These observations suggest a paradoxical pharmacological action of DPH, potentially involving dopaminergic and/or histaminergic pathways. While DPH itself is not a recognized therapeutic agent for the treatment of sexual dysfunctions, these unexpected effects may point toward a novel neurochemical mechanism of sexual excitation in some individuals that warrants further investigation.