Synergistic effect of combined hyperthermia and radiotherapy mediated by AQP5 reduction in pancreatic cancer

20260 citationsJournal Articlegold Open Access

Authors

Jaewan Jeon · Inje University Haeundae Paik Hospital

Hyosun Jang · Korea Institute of Radiological and Medical Sciences

Geumju Park · Inje University Haeundae Paik Hospital

Hyeon Jeong Hwang · Inje University

Mi Lee · Inje University

Minji Kang · Korea Institute of Radiological and Medical Sciences

S J Lee

Abstract

Our findings demonstrate that AQP5 plays a key role in mediating resistance to radiotherapy in PDAC. Its downregulation through combined hyperthermia and radiotherapy enhances radiosensitivity by promoting oxidative stress and blocking survival pathways. AQP5 may serve as a promising molecular target to improve the therapeutic efficacy of combined treatment strategies in pancreatic cancer.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Endoplasmic Reticulum Stress and Disease Eicosanoids and Hypertension Pharmacology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: International Journal of Hyperthermia

Volume 43, Issue 1, pp. 2644451-2644451

DOI: 10.1080/02656736.2026.2644451

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