Recent progress and future directions to advance glioblastoma research: A consensus perspective from the 2024 Christopher Davidson Forum

This position paper from the 2024 Christopher Davidson Forum held at WashU Medicine in Saint Louis provides a comprehensive consensus on scientific advances, key challenges, and future directions in glioblastoma (GBM) research. A multidisciplinary group of over 130 academic neuro-oncology professionals discussed recent developments and existing gaps in understanding the complex tumor biology of GBM tumors, characterizing and overcoming the resistance of GBM to immunotherapeutic approaches, defining tumor-brain interactions and their functional consequences for tumor progression and therapy resistance, and developing and clinically translating novel neuro- and nanotechnologies. We conclude with a call to action for researchers and clinicians in the neuro-oncology field to address fundamental gaps in our understanding of GBM tumor, immune, and neurobiology, and develop critical infrastructure to more rapidly translate novel therapeutic paradigms into the clinic through multi-disciplinary and cross-institutional collaborations.