692 From HSIL to Carcinoma: Spatial Remodeling of the Immune Microenvironment in Anal Squamous Lesions

20260 citationsJournal Articlehybrid Open Access

Authors

Max Molina Ayala · The University of Texas MD Anderson Cancer Center

Sona Chowdhury · University of St. Francis

Heladio P. Ibarguen · The University of Texas MD Anderson Cancer Center

Cynthia Gasper · University of California, San Francisco

Claudio A. Arrechedera · The University of Texas MD Anderson Cancer Center

Auriole Tamegnon · The University of Texas MD Anderson Cancer Center

Abstract

Figure 1 -691.Figure 2 -691.Conclusions: High-risk HPV-associated anorectal glandular lesions may be more common in women.They can mimic colorectal adenomas and adenocarcinomas, co-exist with squamous intra-epithelial lesions, and be associated with aggressive highgrade carcinomas (small cell neuroendocrine carcinoma, sarcomatoid carcinoma, poorly differentiated carcinomas).

Topics & Keywords

Colorectal and Anal Carcinomas Anorectal Disease Treatments and Outcomes Immunotherapy and Immune Responses

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Laboratory Investigation

Volume 106, Issue 3, pp. 104979-104979

DOI: 10.1016/j.labinv.2025.104979

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