Gorab deficiency in skin dermis accelerates aging and is associated with dysregulation of <scp>RCHY1</scp> ‐mediated <scp>P53</scp> ubiquitination

This study elucidates that Gorab mutations in the dermis promote skin aging by causing P53 accumulation and disrupting ECM expression via epigenetic regulation. These findings clarify the biological role of Gorab in skin aging and provide a theoretical basis for related mechanistic research and potential preventive strategies.