The Genetics of TDP-43 Type C Neurodegeneration

20260 citationsJournal Articlegold Open Access

Authors

Malik Nassan · Northwestern University

Ivan N. Ayala · Northwestern University

Jennifer L. Sloan · Translational Genomics Research Institute

Anna Bonfitto · Translational Genomics Research Institute

Bobbi Stark · Translational Genomics Research Institute

Serena Song · Translational Genomics Research Institute

Marcus Naymik

Abstract

This study provides replicated evidence for the association between common variants in <i>ANXA11</i> with TDP-C. Knowing rs1079242-A affects ANXA11 level in CSF, future studies may aim to investigate ANXA11 level as potential CSF biomarker for TDP-C. Moreover, <i>FIG4 and ANXA11</i> have been implicated in the inositol pathway. Our results provide novel insights into the genetic risk of TDP-C and offer new clues about its underpinning mechanisms.

Topics & Keywords

Amyotrophic Lateral Sclerosis Research Neurological diseases and metabolism Genetic Neurodegenerative Diseases

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Neurology Genetics

Volume 12, Issue 2, pp. e200369-e200369

DOI: 10.1212/nxg.0000000000200369

Field-Weighted Citation Impact: 0.00