Digital Health Interventions for Postpartum Depression Following Assisted Reproduction: A Narrative Review

<b>Abstract</b><br /> <b>Background:</b> Postpartum depression (PPD is a prevalent and disabling condition with significant consequences for maternal and infant well-being. Women who conceive through assisted reproductive technologies (ART) may experience distinct psychological vulnerabilities in the postpartum period due to prolonged infertility, treatment-related stress, and prior pregnancy loss. Digital health interventions (DHIs) have emerged as promising tools for addressing perinatal mental health needs; however, their relevance and effectiveness for women following assisted reproduction remain insufficiently synthesized.<br /> <b>Objective:</b> This narrative review aims to critically examine the current evidence on digital health interventions for postpartum depression in the context of assisted reproduction, with a focus on conceptual relevance, methodological strengths and limitations, and implications for clinical practice and future research.<br /> <b>Methods:</b> A structured narrative synthesis was conducted using transparent search procedures across major bibliographic databases, including PubMed, PsycINFO, Scopus, and Web of Science. Peer-reviewed empirical studies, reviews, and key conceptual papers addressing digital mental health interventions for postpartum depression were included, with particular attention to the representation and reporting of ART-conceived populations.<br /> <b>Results:</b> Existing digital interventions—such as mobile health applications, web-based psychotherapy, telepsychology, and emerging AI-supported tools—demonstrate feasibility and acceptability in general postpartum populations. However, ART-specific evidence remains limited, with most studies embedding women who conceive through assisted reproduction within broader perinatal samples and rarely tailoring intervention content to infertility-related psychological experiences. Methodological heterogeneity, small sample sizes, short follow-up periods, and limited subgroup analyses constrain the strength of population-specific conclusions.<br /> <b>Conclusions:</b> Digital health interventions hold considerable promise for addressing postpartum depression following assisted reproduction, but current evidence is largely indirect. Conceptually, DHIs align well with the psychological needs of ART populations; empirically, however, rigorous validation is lacking. Future research should prioritize ART-specific trials, longitudinal designs, participatory co-design approaches, and integration with clinical care pathways to develop effective, personalized, and equitable digital mental health solutions for this high-risk population.