Ocular Surface Microbiota-Derived Lipoteichoic Acid Promotes Dry Eye Disease by Inducing Corneal Inflammation

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Authors

Qingyu An · Shanghai Eye Disease Prevention & Treatment Center

Xinran Qin · Shanghai Ninth People's Hospital

Li Zhong · Shanghai Ninth People's Hospital

Lipu Cui · Shanghai Ninth People's Hospital

Lina Lu · Shanghai Eye Disease Prevention & Treatment Center

Yi Xu · Shanghai Eye Disease Prevention & Treatment Center

Senlin Lin

Abstract

Our findings establish a mechanistic link between OSM-derived LTA and DED. LTA promotes ocular surface inflammation and dysfunction through TLR2 and PAFR signaling, suggesting that targeting microbial products or their receptors, such as PAFR, may offer a novel therapeutic strategy for DED.

Topics & Keywords

Ocular Surface and Contact Lens Ocular Infections and Treatments Corneal Surgery and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 67, Issue 3, pp. 50-50

DOI: 10.1167/iovs.67.3.50

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