Conversion therapy for advanced hepatocellular carcinoma following complete response to transarterial radioembolization combined with atezolizumab and bevacizumab

20260 citationsJournal Articlegold Open Access

Authors

Peter Popovic · University of Ljubljana

Ana Kalamutova · Ljubljana University Medical Centre

Mihajlo Djokic · University of Ljubljana

Anka Cuderman · Ljubljana University Medical Centre

Gasper Boltezar · IEDC-Bled School of Management

Blaz Trotovsek · University of Ljubljana

Abstract

In selected patients, combining transarterial radioembolization with systemic immunotherapy may enable conversion to surgical resection in advanced hepatocellular carcinoma, even with subthreshold tumor radiation doses, highlighting a potential synergistic and abscopal effect between locoregional and systemic therapies.

Topics & Keywords

Hepatocellular Carcinoma Treatment and Prognosis Cholangiocarcinoma and Gallbladder Cancer Studies Cancer Immunotherapy and Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Radiology and Oncology

Volume 60, Issue 1, pp. 40-48

DOI: 10.2478/raon-2026-0015

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