Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era

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Authors

M. Eugenia Socias · University of British Columbia

Jingxin Lei · British Columbia Centre on Substance Use

Vivienne Zhou · University of British Columbia

Rohan Anand · University of British Columbia

Zishan Cui · British Columbia Centre on Substance Use

Stephanie Penta · British Columbia Centre on Substance Use

Marc Larochelle · Boston University

Sara Lodi

Abstract

In this comparative effectiveness study of adults with OUD in a Canadian setting, treatment discontinuation was common. Compared with methadone, SROM was associated with a slightly higher risk of treatment discontinuation and lower adherence but similar mortality risk. The findings suggest either medication may be appropriate if measures are in place to support retention.

Topics & Keywords

Opioid Use Disorder Treatment Substance Abuse Treatment and Outcomes Pain Management and Opioid Use

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Network Open

Volume 9, Issue 3, pp. e262970-e262970

DOI: 10.1001/jamanetworkopen.2026.2970

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