The molecular mechanism underlying the differential subcellular distribution of dystrophin Dp71 isoforms

Alternative splicing at exon 78, generates an NES unique to Dp71f, which dictates subcellular localization and function of this isoform. As a result, Dp71f is efficiently exported and becomes predominantly cytoplasmic, whereas Dp71d, without this NES, is exported less efficiently and remains longer in the nucleus.