Targeting oncogenic NTSR1 with liensinine reprograms Gq-mediated signaling to suppress lung adenocarcinoma

20260 citationsJournal Articlegold Open Access

Authors

Yongfu Wang · Chengdu University of Traditional Chinese Medicine

Wei Liu · Chengdu University of Traditional Chinese Medicine

Pengzhuo Tao · Chengdu University of Traditional Chinese Medicine

Changmin Liu · Chengdu University of Traditional Chinese Medicine

Yizhen Yuan · Chengdu University of Traditional Chinese Medicine

Yajing Xue · Chengdu University of Traditional Chinese Medicine

Hanting Yang · Chengdu University of Traditional Chinese Medicine

Abstract

NTSR1 is a key oncogenic driver in LUAD. Liensinine is a novel NTSR1 antagonist that suppresses tumors by selectively inhibiting Gq signaling and reprogramming the transcriptional landscape.

Topics & Keywords

Neuropeptides and Animal Physiology Cancer, Stress, Anesthesia, and Immune Response Receptor Mechanisms and Signaling

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Chinese Medicine

Volume 21, Issue 1

DOI: 10.1186/s13020-026-01356-6

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