Personalized infliximab rescue therapy to maximize colectomy-free survival in patients with acute severe ulcerative colitis

20260 citationsJournal Article

Authors

Emmanuel Niyigena · UCLouvain

Yannick Hoffert · KU Leuven

Waqqas Afif · McGill University Health Centre

Alessandro Pedicelli · McGill University Health Centre

Xavier Roblin · Clinique des Cèdres

Jurij Hanžel · Ljubljana University Medical Centre

Konstantinos Papamichael · Beth Israel Deaconess Medical Center

Taku Kobayashi

Abstract

We developed a model-based dose-exposure-response framework to predict colectomy risk in ASUC. We integrated the algorithm into an interactive tool to enable individualized infliximab rescue therapy.

Topics & Keywords

Inflammatory Bowel Disease Gut microbiota and health Microscopic Colitis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Crohn s and Colitis

Volume 20, Issue 3

DOI: 10.1093/ecco-jcc/jjag029

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