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In the context of the modern global economy, key drivers of radical change are coming to the fore – transformational transitions to a more complex model – the knowledge economy in its broadest sense. A shift of this magnitude requires new approaches to capacity building for all countries, regardless of their level of development. The emerging imperative provides a wide range of opportunities for developing countries, suggesting a new configuration of the global economic landscape and strategic alliances. The BRICS countries (China, India, Russia, Brazil, UAE, Indonesia, South Africa, Iran, Egypt, Ethiopia) represent a critical mass of players whose actions will determine the direction in which these processes will develop. This article provides a comparative analysis of the innovative and transformational potential of the participants in this block in knowledge-intensive sectors in comparison with one another and with two developed benchmark countries – Austria and Australia. A methodology for calculating a comprehensive index of readiness for the knowledge economy is proposed. The countries under review are ranked on four levels based on the values of this indicator. Their degree of adaptation and readiness for transformational transitions to more complex levels, resource base, educational systems, indicators of patent publication activity, management efficiency, quality of human capital, infrastructure, and global integration capabilities are assessed. Recommendations are presented on policy measures for the development of intellectual economy sectors in the BRICS countries, as well as directions for future research.