Functional xenogeneic hematopoietic cells maintaining donor-dominant identity and immune tolerance enable therapy

Our study provides the first comprehensive functional validation of xenogeneic hematopoietic cells generated in interspecies bioreactors. We definitively show that these cells possess donor-like molecular identities, evade immune rejection, and serve as effective "seed cells" to rescue a wide spectrum of hematologic diseases. This work establishes a transformative paradigm for utilizing interspecies chimeras to overcome critical shortages in transfusion and cellular therapies.