Dietary Intake of n-6 Polyunsaturated Fatty Acid Is Associated With Alzheimer’s Disease Pathology in a Memory Clinic Population

Dietary fatty acids can influence plasma cholesterol levels, which are implicated in the development of Alzheimer’s disease. The relationship between fatty acid intake and cerebral amyloid-beta burden in a memory clinic population was assessed. Sixty-two older participants who underwent a food frequency questionnaire assessment and 18 F-florbetaben positron emission tomography were included in this study. The intake of n-6 polyunsaturated fatty acids was significantly associated with an increased cerebral amyloid-β burden (β = .284, P = .019). The results suggest that a high intake of n-6 polyunsaturated fatty acids may contribute to the development of Alzheimer’s disease.