<scp>SOX5</scp> Overexpression in Schwann Cell Combined With Chitosan‐Based Conduit Promotes Peripheral Nerve Regeneration

20260 citationsJournal Article

Authors

Bo Ma · Peking University

Fengshi Zhang · Peking University

Junyu Su · Shenzhen University

Baixin Gu · Shenzhen University

Lingxin Duan · Shenzhen University

Wen Zhang · Shenzhen University

Yuhui Kou · Peking University

Abstract

Lentivirus-mediated SOX5 overexpression drives Schwann cells toward a repair phenotype and, when integrated with a small-gap chitosan-based conduit, effectively promotes structural and functional nerve regeneration.

Topics & Keywords

Nerve injury and regeneration Virus-based gene therapy research Neurogenesis and neuroplasticity mechanisms

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Journal of the Peripheral Nervous System

Volume 31, Issue 1, pp. e70120-e70120

DOI: 10.1111/jns.70120

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