Comprehensive assessment of the genomic stability of human induced pluripotent stem cells for clinical applications

20260 citationsJournal Articlegold Open Access

Authors

Kehua Zhang · National Medical Products Administration

Tao Na · National Medical Products Administration

Chuncui Jia · National Medical Products Administration

Xianghe Yuan · National Medical Products Administration

Meichen Guo · National Medical Products Administration

Xu Yang · National Medical Products Administration

Min Li · National Medical Products Administration

Wenwen Jia

Abstract

This study established a comprehensive strategy for evaluating the genomic alterations of hiPSCs by integrating karyotyping, OGM, WES, and RNA-seq. This comprehensive strategy can be applied to scenarios such as hiPSC clone screening, establishment of cell bank passages, and quality control of hiPSC-derived products. It provides a reliable genetic stability evaluation protocol to support the safe clinical application of hiPSC-related products.

Topics & Keywords

Pluripotent Stem Cells Research CRISPR and Genetic Engineering Congenital heart defects research

UN Sustainable Development Goals

Partnerships for the goals

Publication Details

Published in: Stem Cell Research & Therapy

DOI: 10.1186/s13287-026-04975-w

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