Radiotherapy for low grade gliomas in children with neurofibromatosis type 1: when there is no other choice. Case Report

Radiotherapy for low-grade gliomas (LGG) in neurofibromatosis type 1 (NF1) is normally avoided, since these children are at an elevated risk of developing severe sequelae. NF1 patients are more predisposed to developing radiation-induced malignancies, as well as vasculopathy. However, radiotherapy may help achieve tumor control in patients with life-threatening complications or a long history of relapse. Here we present two NF1 patients in whom radiotherapy managed to achieve full control of the disease without side effects, sparing those patients from needing further therapies. Literature regarding this aspect is also reviewed.