Novel integrase mutations linked to genotypic DTG resistance in African non-B HIV-1 strains: the DTG RESIST study

20260 citationsJournal Articlehybrid Open Access

Authors

Nuri Han · University of Zurich

Tom Loosli · University of Zurich

Mamatha Sauermann · University of Bern

İpek Çelikağ · University of Bern

Nanina Anderegg · University of Bern

Bertha C Baye · University of KwaZulu-Natal

Carolyn Bolton Moore · Centre for Infectious Disease Research in Zambia

Lydia Buzaalirwa

Abstract

We identified several amino acid substitutions outside the established DRMs that are strongly associated with predicted dolutegravir resistance. Dolutegravir resistance evolution is complex and likely involves mutations not currently classified as DRMs.

Topics & Keywords

HIV/AIDS drug development and treatment HIV Research and Treatment HIV/AIDS Research and Interventions

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 81, Issue 4

DOI: 10.1093/jac/dkag088

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