ТЕРМОДИНАМІЧНІ ВЛАСТИВОСТІ РОЗЧИНІВ 1-[1-(4-МЕТОКСИФЕНІЛ)-2-МЕТИЛ-5-ФЕНІЛ-ПІРРОЛ-3-ІЛ]ЕТАНОНУ В ОРГАНІЧНИХ РОЗЧИННИКАХ

Using the Paal-Knorr reaction, 1-[1-(4-methoxyphenyl)-2-methyl-5-phenyl-pyrrole-3-yl]ethanone was produced. The main stages of synthesis and yield of the target compound are described. The temperature dependence of the solubility of the synthesized compound in the temperature range 275.70–299.40 K was investigated experimentally. The use of the gravimetric method for studying solubility at atmospheric pressure in solvents of different classes is described. Using the Van't Hoff equation, the obtained data were converted to standard molar enthalpies and entropies of dissolution. The enthalpy and entropy of fusion of the obtained substance were determined by the differential thermal method. The equations for converting the research results to standard conditions (298.15 K) are given, and the results are used to calculate the thermodynamic parameters of the mixing and dissolution process of the studied ketone compound with organic solvents. The solubility of 1-[1-(4-methoxyphenyl)-2-methyl-5-phenyl-pyrrole-3-yl]ethanone in all solvents increased with increasing temperature, and these data are in good agreement with the literature data for similar substances. The interaction characteristics of the synthesized substance with solvents of different polarity were established, and the dependencies of the thermal effects of dissolution were obtained. This study of the pyrrole derivative 1-[1-(4-methoxyphenyl)-2-methyl-5-phenyl-pyrrole-3-yl]ethanone is aimed at optimizing the synthesis processes of this compound, its further purification and processing for various uses.