Search for a command to run...
Wenhui Wang,1,* Mingyue Pan,2,* Yan Liu,3 Jin Wang,3 Jin Zhou,1 Yunli Zhao,1 Peiyi Xie,4 Hui Dong,1 Changhua Yi,1 Hui Sun5 1Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210003, People’s Republic of China; 2Department of Hepatopathy, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210003, People’s Republic of China; 3Department of Tuberculosis, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210003, People’s Republic of China; 4Phase I Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210003, People’s Republic of China; 5Department of Nursing, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Sun, Department of Nursing, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, No. 1-1, Zhongfu Road, Gulou District, Nanjing, Jiangsu, 210003, People’s Republic of China, Tel +86 13376084696, Email 3270595980@qq.com Changhua Yi, Clinical Research Center, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, No. 1-1, Zhongfu Road, Gulou District, Nanjing, Jiangsu, 210003, People’s Republic of China, Tel +8615818178091, Email chhuayi@sina.cnObjective: To explore the biosample donation intentions and its influencing factors of infectious disease patients based on the Theory of Planned Behavior so as to provide references for formulating publicity strategy to improve patients’ awareness of donating biosamples and assist in the construction of infectious disease biobank.Methods: By applying the phenomenological research method of qualitative research and using purposive sampling, 15 patients with infectious diseases who were hospitalized in a infectious disease hospital in Jiangsu Province from February to April 2025 were selected for semi-structured interviews. The interview data were collated and analyzed using Nvivo12.0 software and Colaizzi analysis methods.Results: A total of 3 themes and 8 sub-themes were extracted. The themes including: patients with infectious diseases had different attitudes towards biosample donation intentions (positive attitude for donating behaviour were meaningful, negative attitude for no benefit to themselves, and neutral attitude for the unknown risks of donating behaviour); driven by multifaceted subjective norms (family support, medical staff intervention, and social concepts); the perceptual behavioral control was limited (multiple concerns such as privacy protection, research institutions, informed parties, types of donated samples, feedback on research results, costs and compensation, etc).Conclusion: The biosample donation intention of infectious disease patients is influenced by multiple factors. Appropriate and targeted publicity strategies should be formulated, such as differentiated health education for patients with positive/negative/neutral attitudes, and leveraging the guiding role of family members and healthcare providers to enhance patients’ recognition of biosample donation behaviour, give more play to the potential driving role of family, medical staff and social support, explore reasonable and effective informed consent model therefore to assist in the scientific research of infectious diseases and the construction of infectious disease biobank.Keywords: theory of planned behavior, infectious disease, directed tissue donation, behavioral intention, qualitative research