WCN26-4577 HIF-1-mediated macrophage metabolic reprogramming promotes AKI to CKD transition

Macrophage is educated by the tubule epithelial cell with maladaptive repair during the renal maladaptive repair, which is one of the most important characteristic features in acute kidney injury (AKI) to chronic kidney disease (CKD) transition. However, the underlying mechanism of orchestrating characterization of macrophage in renal maladaptive repair remains largely unclear. This study investigated the role of macrophage metabolic reprogramming in maladaptive repair and delineated the contribution of the NF-κB–HIF-1α axis in AKI to CKD transition.