WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegans

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Authors

Nurulhafizah Binti Samsudin · Manchester Academic Health Science Centre

Siyao Wang · Institute of Molecular Biology

Kate Fisher · Manchester Academic Health Science Centre

Gino Poulin · Manchester Academic Health Science Centre

Abstract

Our findings support the notion that WDR-5 profoundly shapes gene expression through RBBP-5-independent mechanisms and possibly beyond H3K4 methylation. Distinguishing between H3K4me-dependent and independent functions of WDR-5 will further understanding of its roles in development and disease.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation Genomics and Chromatin Dynamics

Publication Details

Published in: Epigenetics & Chromatin

DOI: 10.1186/s13072-026-00669-y

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WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegans

Authors

Abstract

Topics & Keywords

Publication Details