Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability

20260 citationsJournal Article

Authors

Colin J. Clark · Jacobson Holman (United States)

Christian Anderson · Jacobson Holman (United States)

Alex Dou · Jacobson Holman (United States)

Jason M. Dierdorff · Jacobson Holman (United States)

Jason D. Galpin · Jacobson Holman (United States)

Lionel Gissot · Jacobson Holman (United States)

Susan Thompson

Abstract

These results reveal a surprising chamber-specific isoform landscape of cardiac sodium currents, which may underlie the right ventricular predominant phenotype of Brugada syndrome. These data highlight non-Na<sub>V</sub>1.5 isoforms as potential mediators of chamber-specific cardiac pathologies and as pharmacological targets.

Topics & Keywords

Ion channel regulation and function Cardiac electrophysiology and arrhythmias Ion Transport and Channel Regulation

Publication Details

Published in: Circulation Research

DOI: 10.1161/circresaha.125.328159

Field-Weighted Citation Impact: 0.00

Command Palette

Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability

Authors

Abstract

Topics & Keywords

Publication Details