WCN26-4806 PREDICTIVE MODEL FOR IN-HOSPITAL MORTALITY IN PATIENTS WITH PROFOUND HYPONATREMIA USING BASELINE DATA

Results:The median (IQR) age and dialysis duration were 68 (60, 75) years and 64 (29, 133) months, respectively.The cohort was divided into tertiles based on CL (T1, 86-100 mEq/L, N = 544; T2, 101-103 mEq/L, N = 508; T3, 104-116 mEq/L, N = 601).We identified 467 cases with ACM.Kaplan-Meier analysis showed an inverse association between CL and ACM.The inverse association was significant even in Cox regression analysis adjusted for 24 potential confounders with the hazard ratio [95%CI] of1.69 [1.34, 2.13] for T1 and 1.37 [1.08, 1.74] for T2 as compared to T3.The inverse association was consistent across various subgroups and remained significant after additional adjustment for serum Na, K, use of RASi, and use of loop diuretics.Conclusion: A lower serum CL is a novel and independent predictor of ACM in patients on MHD.Further studies are needed to elucidate the mechanisms behind the observed association and to clarify the clinical impact of this observation.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.