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Mixed Reality (MR) in the healthcare field provides innovative tools for training, diagnosis, and treatment. It allows professionals to practice surgical procedures in a controlled, risk-free environment, improving skill and reducing error margins, thus offering a more interactive and personalized option for patients. MR aids in the detailed visualization of bone structures and tissues, enabling more precise planning. To conduct this systematic review, a rigorous and structured approach was followed to identify, evaluate, and synthesize relevant studies on the application of MR in orthopedic surgery. The following keywords and combinations were used: “Extended Reality”, “Mixed Reality”, “Orthopedic Surgery”, and “Surgical Planner” in PubMed and Web of Science over the last 10 years. Studies included in this review met the following exclusion criteria: articles that did not use these technologies, studies on other types of surgery, or were review articles. MR has opened new possibilities in the field of surgery, transforming both the training of medical professionals and the surgical interventions themselves. While there are still challenges in its widespread implementation, the benefits it offers in terms of precision, personalization, and efficiency are undeniable. As this technology continues to evolve, it is expected to have an even greater impact on the medicine of the future, making surgeries safer and improving patient outcomes.