Prediction of Osteoporosis and Fragility Fracture Risk Using Proximal Humerus CT Value from Chest CT: A Development and Validation Study

The Clinical + CT model, which integrates clinical factors with proximal humerus CT values from routine chest CT scans, can effectively identify individuals with osteoporosis and high fracture risk, offering a simple and effective tool for opportunistic screening. The models demonstrate good reliability, and decision curve analysis indicates a high net clinical benefit for both endpoints.