Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy–Naïve Localized Prostate Cancer

20260 citationsJournal Article

Authors

Eva Apostolov · The University of Sydney

Daniel L. Roden · The University of Sydney

Holly Holliday · The University of Sydney

Aurélie Cazet · The University of Sydney

Kate Harvey · Garvan Institute of Medical Research

Hanyun Zhang · Garvan Institute of Medical Research

Sunny Z. Wu

Abstract

Development of a single-cell RNA-sequencing and spatial transcriptomics cellular reference of localized prostate cancer enables identification of a spectrum of malignant epithelial phenotypes and discovery of a perineural class of fibroblast.

Topics & Keywords

Single-cell and spatial transcriptomics Prostate Cancer Treatment and Research Cancer Immunotherapy and Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Research

DOI: 10.1158/0008-5472.can-25-1202

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