WCN26-5681 DESIGN OF A PHASE 2b/3 ADAPTIVE, RANDOMIZED, ACTIVE-CONTROLLED TRIAL (OLYMPUS) EVALUATING POVETACICEPT IN PRIMARY MEMBRANOUS NEPHROPATHY

Methods:We retrospectively analyzed patients diagnosed with IgAN between 2018 and 2019.Patients were categorized based on outpatient visit continuity into two groups: regular follow-up and follow-up interruption (defined as $ three months beyond appointment day without nephrology visit).We compared variables such as age, sex, medication status, serum creatinine, proteinuria, certification for intractable disease, steroid therapy, and tonsillectomy.Results: Among 87 patients, 11 (12.6%)experienced follow-up interruption.Compared to those with regular follow-up, the interruption group tended be younger and to had lower serum creatinine levels.The proportion of patients with certification for intractable disease was significantly higher in the regular follow-up group.Furthermore, in the interruption group, many cases involved no prescribed medication.There were no significant differences in sex, steroid therapy, or tonsillectomy between the group.Conclusion: This study identified characteristics of patients with IgAN who voluntarily discontinued follow-up.The discontinuation among younger patients may be due to busy schedule difficulties in maintaining regular visits.In addition, patients with lower serum creatinine levels or those without prescribed medication may have a diminished awareness of importance of regular follow-up.Furthermore, patient with certification for intractable disease were less likely to discontinue care, possibly due to improved disease awareness and reduced financial burden associated with the certification.Discontinuation of outpatient follow-up in IgAN was more frequent among younger, better renal function and without certification for intractable disease.Education emphasizing the importance of regular follow-up is particularly needed for these patients.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.