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The montpellier’s cryoEM community and the requested BAG includes the groups from CBS, the IGF, of the IRIM and the LPHI. We are currently running several research projects requiring single-particles cryoEM data collection. We have both internal projects and longterm collaborative projects that currently relies on access to high-end 200KeV microscopes for sample screening mainly (METI Toulouse, Marseille, IBS Grenoble, Karolinska Institute) and to 300KeV electron microscopes for data collection ( ESRF running proposals, Karolinska institute, MRC-LMB, NCBS Bangalore, Thermofisher). In this context, we investigate the structural basis of important therapeutic targets. The CBS teams characterises nuclear hormone receptors, nucleotide binding proteins, enzymes, and DNA ORIGAMI. The IGF characterize GPCRs such as mGluRs, and related transmembrane proteins. The IRIM and LPHI are focusing on several therapeutic targets, including membrane proteins.